Description
ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
Product information
CAS Number: 106392-48-7
Molecular Weight: 272.34
Formula: C16H20N2O2
Chemical Name: (2E)-2-cyano-3-[4-hydroxy-3,5-bis(propan-2-yl)phenyl]prop-2-enamide
Smiles: CC(C)C1=CC(=CC(C(C)C)=C1O)/C=C(\C#N)/C(N)=O
InChiKey: HMLQHJRJKQDTKW-LFYBBSHMSA-N
InChi: InChI=1S/C16H20N2O2/c1-9(2)13-6-11(5-12(8-17)16(18)20)7-14(10(3)4)15(13)19/h5-7,9-10,19H,1-4H3,(H2,18,20)/b12-5+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 110 mg/mL (403.91 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.