2-Methoxyidazoxan monohydrochloride


Catalog No. Size PriceQuantity
M21903-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2).

Product information

CAS Number: 109544-45-8

Molecular Weight: 270.71

Formula: C12H15ClN2O3

Chemical Name: 2-[(2S)-2-methoxy-2,3-dihydro-1,4-benzodioxin-2-yl]-4,5-dihydro-1H-imidazole hydrochloride

Smiles: Cl.CO[C@@]1(COC2=CC=CC=C2O1)C1NCCN=1

InChiKey: IMPOOMVZVWKSAP-UTONKHPSSA-N

InChi: InChI=1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H/t12-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement.

Products are for research use only. Not for human use.

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