Hexadecyl Methyl Glycerol

Catalog No. Size PriceQuantity
M22160-C Contact sales@xcessbio.com for quotation $100Unavailable


Hexadecyl Methyl Glycerol, also known as AMG-C16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase C with IC50 value of about 80 μM . Protein kinase C is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (PMA), a substance that activates both the respiratory burst and protein kinase C. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+) . Hexadecyl Methyl Glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. Hexadecyl Methyl Glycerol inhibited the activation of purified protein kinase C by diacylglycerol in the presence of phosphatidylserine. In neutrophilic granulocytes, Hexadecyl Methyl Glycerol inhibited the respiratory burst induced by PDBu in a dose-dependent way. In neutrophils, Hexadecyl Methyl Glycerol inhibited the phosphorylation of purified 47-kDa protein, an important substrate of protein kinase C .

Product information

CAS Number: 96960-92-8

Molecular Weight: 330.55

Formula: C20H42O3

Chemical Name: 3-(hexadecyloxy)-2-methoxypropan-1-ol



InChi: InChI=1S/C20H42O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23-19-20(18-21)22-2/h20-21H,3-19H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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