BAY 73-1449

Catalog No. Size PriceQuantity
M23622-C Contact for quotation $100Unavailable


BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure.

Product information

CAS Number: 693790-96-4

Molecular Weight: 425.48

Formula: C26H23N3O3

Chemical Name: (2S)-2-({6-[4-(benzyloxy)phenyl]pyrimidin-4-yl}amino)-3-phenylpropanoic acid

Smiles: OC(=O)[C@H](CC1C=CC=CC=1)NC1=CC(=NC=N1)C1C=CC(=CC=1)OCC1C=CC=CC=1


InChi: InChI=1S/C26H23N3O3/c30-26(31)24(15-19-7-3-1-4-8-19)29-25-16-23(27-18-28-25)21-11-13-22(14-12-21)32-17-20-9-5-2-6-10-20/h1-14,16,18,24H,15,17H2,(H,30,31)(H,27,28,29)/t24-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (587.57 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats. BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats.

Products are for research use only. Not for human use.

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