Bcl-2/Bcl-xl inhibitor 1

Catalog No. Size PriceQuantity
M23775-C Contact sales@xcessbio.com for quotation $100Unavailable


Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.

Product information

CAS Number: 2180923-05-9

Molecular Weight: 882.42

Formula: C45H48ClN7O8S

Chemical Name: 4-(4-{[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl}piperazin-1-yl)-N-[4-({[(2S)-1,4-dioxan-2-yl]methyl}amino)-3-nitrobenzenesulfonyl]-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide

Smiles: [O-][N+](=O)C1=CC(=CC=C1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)C1=CC=C(C=C1OC1=CN=C2NC=CC2=C1)N1CCN(CC2CCC3(CC=2C2C=CC(Cl)=CC=2)CCC3)CC1


InChi: InChI=1S/C45H48ClN7O8S/c46-33-4-2-30(3-5-33)39-25-45(12-1-13-45)14-10-32(39)28-51-16-18-52(19-17-51)34-6-8-38(42(23-34)61-35-22-31-11-15-47-43(31)49-26-35)44(54)50-62(57,58)37-7-9-40(41(24-37)53(55)56)48-27-36-29-59-20-21-60-36/h2-9,11,15,22-24,26,36,48H,1,10,12-14,16-21,25,27-29H2,(H,47,49)(H,50,54)/t36-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bcl-2/Bcl-xl inhibitor 1 (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells.

Products are for research use only. Not for human use.

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