PC Mal-NHS carbonate ester

Catalog No. Size PriceQuantity
M23833-C Contact sales@xcessbio.com for quotation $100Unavailable


PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Product information

CAS Number: 1408057-91-9

Molecular Weight: 562.48

Formula: C24H26N4O12

Chemical Name: 1-[4-(3-{[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamoyl}propoxy)-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxopyrrolidin-1-yl carbonate

Smiles: COC1=CC(C(C)OC(=O)ON2C(=O)CCC2=O)=C(C=C1OCCCC(=O)NCCN1C(=O)C=CC1=O)[N+]([O-])=O


InChi: InChI=1S/C24H26N4O12/c1-14(39-24(34)40-27-22(32)7-8-23(27)33)15-12-17(37-2)18(13-16(15)28(35)36)38-11-3-4-19(29)25-9-10-26-20(30)5-6-21(26)31/h5-6,12-14H,3-4,7-11H2,1-2H3,(H,25,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Products are for research use only. Not for human use.

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