ACT 178882

Catalog No. Size PriceQuantity
M23965-C Contact for quotation $100Unavailable


ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.

Product information

CAS Number: 1007392-69-9

Molecular Weight: 647.03

Formula: C33H38Cl3N3O4

Chemical Name: (3R,4S)-N-{[2-chloro-5-(2-methoxyethyl)phenyl]methyl}-N-cyclopropyl-4-{6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl}piperidine-3-carboxamide

Smiles: CC1C=C(Cl)C(OCCOC2=CC=C(C=N2)[C@H]2CCNC[C@@H]2C(=O)N(CC2=CC(CCOC)=CC=C2Cl)C2CC2)=C(Cl)C=1


InChi: InChI=1S/C33H38Cl3N3O4/c1-21-15-29(35)32(30(36)16-21)43-14-13-42-31-8-4-23(18-38-31)26-9-11-37-19-27(26)33(40)39(25-5-6-25)20-24-17-22(10-12-41-2)3-7-28(24)34/h3-4,7-8,15-18,25-27,37H,5-6,9-14,19-20H2,1-2H3/t26-,27+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The median time to Cmax (tmax) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t½) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for Cmax and 2.02 (1.75 to 2.34) for AUC∞, indicating a significant interaction between ACT 178882 and diltiazem.

Products are for research use only. Not for human use.

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