Src Inhibitor 3

Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signaling.

Product information

CAS Number: 2380027-49-4

Molecular Weight: 671.12

Formula: C34H32ClFN8O4

Chemical Name: N-(3-chloro-4-{6-methoxypyrazolo[1,5-a]pyridine-3-amido}phenyl)-1-[1-(3-cyano-3,3-dimethylpropanoyl)piperidin-4-yl]-5-fluoro-1H-indazole-3-carboxamide

Smiles: CC(C)(CC(=O)N1CCC(CC1)N1N=C(C2=CC(F)=CC=C12)C(=O)NC1=CC(Cl)=C(C=C1)NC(=O)C1C=NN2C=C(C=CC2=1)OC)C#N

InChiKey: LQQYARMJQBHKQQ-UHFFFAOYSA-N

InChi: InChI=1S/C34H32ClFN8O4/c1-34(2,19-37)16-30(45)42-12-10-22(11-13-42)44-29-8-4-20(36)14-24(29)31(41-44)33(47)39-21-5-7-27(26(35)15-21)40-32(46)25-17-38-43-18-23(48-3)6-9-28(25)43/h4-9,14-15,17-18,22H,10-13,16H2,1-3H3,(H,39,47)(H,40,46)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (186.26 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Src Inhibitor 3 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation.

Products are for research use only. Not for human use.