Description
Product Information
| Purity: | ≥98% for each compound |
| Storage: | 4oC for 3 month. -20oC for 6 month. |
| Cocktail 1000X Formulation: | 2.5 mM 1-Azakenpaullone, 0.5 mM WS6 and 0.2 mM TTNPB |
Biological Activity:
Induction of mouse totipotent stem cells by a defined chemical cocktail. The study demonstrate induction and long-term maintenance of TotiSCs from mouse pluripotent stem cells (PSCs) by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. The chemical approach for TotiSCs induction and maintenance provides a defined in vitro system to manipulate and understand totipotent state towards creating life from non-germline.
References:
- Hu, Y. et al. Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature https://doi.org/10.1038/s41586-022-04967-9 (2022).
Products are for research use only. Not for human use.
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