Ryuvidine, Lysine Methyltransferase SETD8 Inhibitor

Ryuvidine is an inhibitor of SETD8 with cellular activity. It also acts as a CDK4 inhibitor and inducer of the DNA damage response.

Product information

CAS Number: 265312-55-8

Molecular Weight: 284.33

Formula: C15H12N2O2S

Chemical Name: 2-methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione

Smiles: CC1C=CC(=CC=1)NC1=CC(=O)C2SC(C)=NC=2C1=O

InChiKey: HFPLHASLIOXVGS-UHFFFAOYSA-N

InChi: InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 20 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Ryuvidine was used at 10 µM final concentration in various in vitro assays.

References:

1. Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. (2000) Bioorg Med Chem Lett. 10(5):461-4.
2. Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. (2014) ACS Chem Biol. 9(11):2471-8.

Products are for research use only. Not for human use.

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