PD-151746


Catalog No. size PriceQuantity
M6598-2 2mg solid $117
M6598-10 10mg solid $470

Description

Cas:179461-52-0

Product Information

PD-151746 is an inhibitor of calpains 1 and 2.

 

Chemical Formula: C11H8FNO2S

 

Exact Mass: 237.026

 

Molecular Weight: 237.24

 

Elemental Analysis: C, 55.69; H, 3.40; F, 8.01; N, 5.90; O, 13.49; S, 13.51

 

Synonym: 

 

PD-151746

PD 151746

PD151746

 

Chemical Name:  

3-(5-Fluoro-3-indolyl)-2-mercapto-2-propenoic Acid

 

InChi Key:

HWMQHECFXSVZGN-KMKOMSMNSA-N

 

InChi Code:   InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-

 

Smiles Code:

O=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

 

 

References

 

  1. Lei H, Li X, Jing B, Xu H, Wu Y. Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. PLoS One. 2017 Jan 6;12(1):e0169788. doi: 10.1371/journal.pone.0169788. eCollection 2017. PubMed PMID: 28060905; PubMed Central PMCID: PMC5218466.

 

  1. Fujita H, Kato T, Watanabe N, Takahashi T, Kitagawa S. Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. Arch Biochem Biophys. 2011 Dec 15;516(2):121-7. doi: 10.1016/j.abb.2011.09.017. Epub 2011 Oct 7. PubMed PMID: 22005393.

 

  1. Meier M, Klein HH, Kramer J, Drenckhan M, Schutt M. Calpain inhibition impairs glycogen syntheses in HepG2 hepatoma cells without altering insulin signaling. J Endocrinol. 2007 Apr;193(1):45-51. PubMed PMID: 17400802.

 

  1. Jost MM, Jost P, Klein J, Klein HH. The beta3-adrenergic agonist CL316,243 inhibits insulin signaling but not glucose uptake in primary human adipocytes. Exp Clin Endocrinol Diabetes. 2005 Sep;113(8):418-22. PubMed PMID: 16151974.

 

  1. Porn-Ares MI, Saido TC, Andersson T, Ares MP. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J. 2003 Sep 1;374(Pt 2):403-11. PubMed PMID: 12775216; PubMed Central PMCID: PMC1223604.

 

Products are for research use only. Not for human use.

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