MDK-8650


Catalog No. size PriceQuantity
M6817-2 2mg solid $95
M6817-10 10mg solid $401

Description

Cas:736048-65-0

Product Information

MDK-8650, also known as PKC-theta inhibitor, is a selective PKC-θinhibitor, with an IC50 of 12 nM.

 

Chemical Formula: C20H25F3N6O3

 

Exact Mass: 454.194

Molecular Weight: 454.4542

 

Elemental Analysis: C, 52.86; H, 5.55; F, 12.54; N, 18.49; O, 10.56

 

Synonym:

 

MDK8650

PKC-theta inhibito

 

Chemical Name: N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitro-N2-(2-(trifluoromethoxy)benzyl)pyrimidine-2,4-diamine

 

InChi Key:

HKOWATVSFKRXRW-UHFFFAOYSA-N

 

InChi Code: InChI=1S/C20H25F3N6O3/c21-20(22,23)32-17-4-2-1-3-15(17)11-26-19-27-12-16(29(30)31)18(28-19)25-10-14-7-5-13(9-24)6-8-14/h1-4,12-14H,5-11,24H2,(H2,25,26,27,28)

 

Smiles Code:

FC(F)(F)OC1=CC=CC=C1CNC2=NC=C([N+]([O-])=O)C(NCC3CCC(CN)CC3)=N2

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med hem Lett. 2007 Jan 1;17(1):225-30. Epub 2006 Oct 19. PubMed PMID: 17055721.

 

Products are for research use only. Not for human use.

 

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