Decursinol angelate

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. It improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast.

Product information

CAS Number: 130848-06-5

Molecular Weight: 328.36

Formula: C19H20O5

Synonym:

Acutilobin

UNII-LXU5241LCL

Chemical Name: (S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (Z)-2-methylbut-2-enoate

Smiles: C/C(=C/C)/C(=O)O[C@H]1CC2=CC3C=CC(=O)OC=3C=C2OC1(C)C

InChiKey: AGABNGOXUSXQDD-XKGFZTIGSA-N

InChi: InChI=1S/C19H20O5/c1-5-11(2)18(21)23-16-9-13-8-12-6-7-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/b11-5-/t16-/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Kim S, Kim JE, Kim N, Joo M, Lee MW, Jeon HJ, Ryu H, Song IC, Song GY, Lee HJ. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. Am J Cancer Res. 2019 Sep 1;9(9):2007-2018. eCollection 2019. PubMed PMID: 31598401; PubMed Central PMCID: PMC6780662.
2. Chang SN, Khan I, Dey DK, Cho KH, Hwang BS, Bae KB, Kang SC, Park JG. Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. Food Chem Toxicol. 2019 Oct;132:110699. doi: 10.1016/j.fct.2019.110699. Epub 2019 Jul 24. PubMed PMID: 31351099.
3. Jung MY, Seo CS, Baek SE, Lee J, Shin MS, Kang KS, Lee S, Yoo JE. Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells. Biomolecules. 2019 Jul 10;9(7). pii: E272. doi: 10.3390/biom9070272. PubMed PMID: 31295870; PubMed Central PMCID: PMC6681368.

Products are for research use only. Not for human use.