ICN37805


Catalog No. size PriceQuantity
M7071-2 2mg solid $75
M7071-10 10mg solid $225

Description

ICN37805 is an important intermediate to synthesize antiviral drug remdesivir. This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number or its molecule weight if its CAS number is not available (see MedKoo Chemical Nomenclature, https://www.medkoo.com/page/naming).

Product information

CAS Number: 1191237-80-5

Molecular Weight: 331.33

Formula: C15H17N5O4

Synonym:

Remdesivir related compound 7

ICN-37805

ICN 37805

Chemical Name: (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile

Smiles: CC1(C)O[C@@H]2[C@H](O1)[C@@H](CO)O[C@@]2(C#N)C1=CC=C2C(N)=NC=NN21

InChiKey: IJCOKJGMVJGKBB-CGEWXTDFSA-N

InChi: InChI=1S/C15H17N5O4/c1-14(2)23-11-9(5-21)22-15(6-16,12(11)24-14)10-4-3-8-13(17)18-7-19-20(8)10/h3-4,7,9,11-12,21H,5H2,1-2H3,(H2,17,18,19)/t9-,11-,12-,15+/m1/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′, 3′-acetonide protected analogue of Remdesivir.

References:

  1. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.
  2. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

Products are for research use only. Not for human use.

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