SNIPER(CRABP)-11


Catalog No. size PriceQuantity
M7104-2 2mg solid $346
M7104-10 10mg solid $1,396

Description

Cas:1384275-50-6

Product Information

SNIPER(CRABP)-11, also known as PROTAC cIAP1 degrader-​4, is a potent protein degrader. SNIPER(CRABP)-11 displayed degradation activity toward the mitochondrial CRABP-II protein.、

 

Chemical Formula: C60H83N7O10

 

Exact Mass: 1061.6201

 

Molecular Weight: 1062.36

 

Elemental Analysis: C, 67.84; H, 7.88; N, 9.23; O, 15.06

 

Synonym: 

 

SNIPER(CRABP)-11

SNIPER(CRABP)11

SNIPER(CRABP) 11

SN-11

SN 11

SN11

PROTAC cIAP1 degrader-​4

 

Chemical Name: (2E,4E,6E,8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1,4,15-trioxo-8,11-dioxa-2,5,14-triazahexadecan-16-yl)oxy)imino)-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

 

InChi Key: 

JKPIDKPKBOTXBU-HMLGKSOISA-N

 

InChi Code: InChI=1S/C60H83N7O10/c1-41(19-17-20-42(2)39-52(69)70)28-29-48-43(3)49(30-31-60(48,5)6)66-77-40-51(68)62-32-35-75-37-38-76-36-33-63-58(73)55(53(45-21-11-8-12-22-45)46-23-13-9-14-24-46)65-57(72)50-27-18-34-67(50)59(74)54(47-25-15-10-16-26-47)64-56(71)44(4)61-7/h8-9,11-14,17,19-24,28-29,39,44,47,50,53-55,61H,10,15-16,18,25-27,30-38,40H2,1-7H3,(H,62,68)(H,63,73)(H,64,71)(H,65,72)(H,69,70)/b20-17+,29-28+,41-19+,42-39+,66-49+/t44-,50-,54-,55-/m0/s1

Smiles Code:

CC(/C(CCC(C)1C)=N/OCC(NCCOCCOCCNC([C@H](C(C2=CC=CC=C2)C3=CC=CC=C3)NC([C@@H]4CCCN4C([C@H](C5CCCCC5)NC([C@H](C)NC)=O)=O)=O)=O)=O)=C1/C=C/C(C)=C/C=C/C(C)=C/C(O)=O

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. Okuhira K, Shoda T, Omura R, et al. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017;91(3):159–166. doi:10.1124/mol.116.105569

 

Products are for research use only. Not for human use.

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