Nitazoxanide

Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths. Emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.

Product information

CAS Number: 55981-09-4

Molecular Weight: 307.28

Formula: C12H9N3O5S

Synonym:

Alinia

Colufase

Daxon

Nitazoxamide

Nitazoxanide

Chemical Name: [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

Smiles: CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C(S1)[N+]([O-])=O

InChiKey: YQNQNVDNTFHQSW-UHFFFAOYSA-N

InChi: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

References:

1. Di Santo N, Ehrisman J. A functional perspective of nitazoxanide as a potential anticancer drug. Mutat Res. 2014 Oct;768:16-21. doi: 10.1016/j.mrfmmm.2014.05.005. Epub 2014 Jun 2. Review. PubMed PMID: 25847384.
2. Rossignol JF. Nitazoxanide: a first-in-class broad-spectrum antiviral agent. Antiviral Res. 2014 Oct;110:94-103. doi: 10.1016/j.antiviral.2014.07.014. Epub 2014 Aug 7. Review. PubMed PMID: 25108173.
3. Nikolova K, Gluud C, Grevstad B, Jakobsen JC. Nitazoxanide for chronic hepatitis C. Cochrane Database Syst Rev. 2014 Apr 6;4:CD009182. doi: 10.1002/14651858.CD009182.pub2. Review. PubMed PMID: 24706397.

Products are for research use only. Not for human use.