LY 2886721 Hydrochloride


Catalog No. size PriceQuantity
M7218-2 2mg solid $118
M7218-10 10mg solid $476

Description

Cas:1262036-49-6

Product Information

LY 2886721 Hydrochloride is a potent and selective β-secretase inhibitor.

 

Chemical Formula: C18H17ClF2N4O2S

Exact Mass: 426.0729

 

Molecular Weight: 426.8668

 

Elemental Analysis: C, 50.65; H, 4.01; Cl, 8.30; F, 8.90; N, 13.13; O, 7.50; S, 7.51

 

Synonym:

 

LY 2886721 Hydrochloride

LY-2886721 hydrochloride

1262036-49-6

UNII-HW8GJY7V7R

HW8GJY7V7R

N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

LY 2886721 hydrochloride

SCHEMBL970474

DTXSID10155116

BCP24785

BS-14794

Q27280128

 

Chemical Name: N-(3-((4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

 

InChi Key:

JHHMCINLHBUFHB-GHDSXOKHSA-N

 

InChi Code: InChI=1S/C18H16F2N4O2S.ClH/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18;/h1-6,10H,7-9H2,(H2,21,24)(H,23,25);1H/t10-,18-;/m0./s1

 

Smiles Code:

[H][C@@]12COC[C@@]1(N=C(N)SC2)C3=CC(NC(C4=CC=C(F)C=N4)=O)=CC=C3F.Cl

 

 

Technical Data:

 

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

 

 

References

 

  1. May et al (2015) The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs and humans. J.Neurosci. 35 1199 PMID: 25609634

 

Products are for research use only. Not for human use.

 

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