S-Adenosyl-L-homocysteine (SAH)

S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.

Product information

CAS Number: 979-92-0

Molecular Weight: 384.41

Formula: C14H20N6O5S

Synonym:

S-Adenosylhomocysteine

AdoHcy

Formycinylhomocysteine

Chemical Name: (5S)-2-amino-5-((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-mercaptopentanoic acid

Smiles: NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H]([C@@H](S)CCC(N)C(O)=O)[C@@H](O)[C@H]1O

InChiKey: QLARQQFYXNHLNY-QMEGSSTCSA-N

InChi: InChI=1S/C14H20N6O5S/c15-5(14(23)24)1-2-6(26)10-8(21)9(22)13(25-10)20-4-19-7-11(16)17-3-18-12(7)20/h3-6,8-10,13,21-22,26H,1-2,15H2,(H,23,24)(H2,16,17,18)/t5?,6-,8-,9+,10+,13+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 77 mg/mL (200.31 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

S-Adenosyl-L-homocysteine (SAH) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 ± 0.1 μM. While the presence of S-Adenosyl-L-homocysteine has no significant effects on ALKBH5 activity.

References:

1. Fengling Li, et al. J Biomol Screen. 2016 Mar;21(3):290-7.

Products are for research use only. Not for human use.