Troxerutin

Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree. It is used as a vasoprotective. Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet.

Product information

CAS Number: 7085-55-4

Molecular Weight: 742.68

Formula: C33H42O19

Synonym:

Factor P-zyma

Flebil

Helveton

Pherarutin

Veinamitol Pulver

Venaroid

Veno S

L Venoruton

Venoruton P4

Vitamin P4

Z 6000

Chemical Name: 2-(3, 4-bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S, 3R, 4S, 5S, 6R)-3, 4, 5-trihydroxy-6-((((2R, 3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

Smiles: C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3C(=O)C4=C(C=C(C=C4O)OCCO)OC=3C3=CC(OCCO)=C(C=C3)OCCO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

InChiKey: IYVFNTXFRYQLRP-VVSTWUKXSA-N

InChi: InChI=1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(134.64 mM). Water: 100 mg/mLwarmed(134.64 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Troxerutin (Trihydroxyethylrutin), a natural bioflavonoid isolated from Sophora japonica., has been reported to have many benefits and medicinal properties. Troxerutin reduces omocysteine, alpha-amino adipic acid, cholesterol, triglycerides, and LDL apo B levels in plasma of patients of acute myocardial infarction. Troxerutin decreases erythrocyte aggregation and shows positive action on stasis, capillary perfusion and trophic complications of chronic venous insufficiency. Troxerutin also attenuates cognitive impairment and oxidative stress induced by D-galactose in mouse brain through decreasing advanced glycation end products, reactive oxygen species and protein carbonyl levels and enhancing phosphoinositide 3-kinase/Akt activation.

References:

1. Lu J, et al. Brain, 2011, 134(Pt 3), 783-797.
2. Boisseau MR, et al. J Cardiovasc Surg (Torino), 1995, 36(4), 369-374.
3. Olszewski AJ, et al. Atherosclerosis, 1989, 75(1), 1-6.

Products are for research use only. Not for human use.